Počet záznamů: 1
The effect of alpha-tocopheryl succinate on succinate respiration in rat liver mitochondria
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SYSNO ASEP 0457718 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The effect of alpha-tocopheryl succinate on succinate respiration in rat liver mitochondria Tvůrce(i) Sobotka, O. (CZ)
Drahota, Zdeněk (FGU-C) RID, ORCID
Kučera, O. (CZ)
Endlicher, R. (CZ)
Rauchová, Hana (FGU-C) RID, ORCID
Červinková, Z. (CZ)Zdroj.dok. Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 64, Suppl.5 (2015), S609-S615Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova tocopheryl succinate ; Complex II ; liver ; mitochondria ; homogenate ; hepatocytes Vědní obor RIV ED - Fyziologie Institucionální podpora FGU-C - RVO:67985823 UT WOS 000372421900007 EID SCOPUS 84963811905 Anotace We compared the effect of alpha-tocopheryl succinate (TOS) on
succinate-dependent respiration in rat liver mitochondria,
homogenate and permeabilized hepatocytes in both a coupled
and uncoupled state. In isolated mitochondria, a significant
inhibitory effect was observed at a concentration of 5 µM, in liver
homogenate at 25 µM and in permeabilized hepatocytes at
50 µM. The inhibitory effect of TOS on succinate respiration in an
uncoupled state was less pronounced than in a coupled state in
all the experimental models tested. When the concentration
dependence of the TOS inhibitory effect was tested, the most
sensitive in both states were isolated mitochondria; the most
resistant were permeabilized hepatocytes
Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2016
Počet záznamů: 1