Počet záznamů: 1
Synthesis and Comparative Study of Ammonium and Phosphonium Terminated Carbosilane Dendrimers.
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SYSNO ASEP 0457374 Document Type C - Proceedings Paper (int. conf.) R&D Document Type The record was not marked in the RIV Title Synthesis and Comparative Study of Ammonium and Phosphonium Terminated Carbosilane Dendrimers. Author(s) Strašák, Tomáš (UCHP-M) RID, ORCID, SAI
Müllerová, Monika (UCHP-M) RID, ORCID, SAI
Čermák, Jan (UCHP-M) RID, ORCID, SAI
Malý, J. (CZ)
Malý, M. (CZ)
Wróbel, D. (CZ)Source Title Poster Communications Abstracts. - - : -, 2015 - ISBN N Pages s. 206 Number of pages 1 s. Publication form Online - E Action EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry /6./ Event date 15.11.2015 - 18.11.2015 VEvent location Rehovot Country IL - Israel Event type WRD Language eng - English Country IL - Israel Keywords CB-DDM ; phosphorium ; ammonium Subject RIV CC - Organic Chemistry Institutional support UCHP-M - RVO:67985858 Annotation Here we report synthesis of new library of CB-DDM with both ammonium and phosphonium groups on the periphery. To evaluate the effect of substitution of substitution of nitrogen atom by phosphorus we prepared two series of identical CS_DDM in 1st – 3rd generations which differs only in onium groups (N or P). Comparative study of their cytotoxicity, the ability to form dendriplexes and their transfections through cell membrane will be presented. The results are supported by computational modeling.
Workplace Institute of Chemical Process Fundamentals Contact Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Year of Publishing 2016
Počet záznamů: 1