- Synthesis and Comparative Study of Ammonium and Phosphonium Terminate…
Počet záznamů: 1  

Synthesis and Comparative Study of Ammonium and Phosphonium Terminated Carbosilane Dendrimers.

  1. 1.
    SYSNO ASEP0457374
    Document TypeC - Proceedings Paper (int. conf.)
    R&D Document TypeThe record was not marked in the RIV
    TitleSynthesis and Comparative Study of Ammonium and Phosphonium Terminated Carbosilane Dendrimers.
    Author(s) Strašák, Tomáš (UCHP-M) RID, ORCID, SAI
    Müllerová, Monika (UCHP-M) RID, ORCID, SAI
    Čermák, Jan (UCHP-M) RID, ORCID, SAI
    Malý, J. (CZ)
    Malý, M. (CZ)
    Wróbel, D. (CZ)
    Source TitlePoster Communications Abstracts. - - : -, 2015 - ISBN N
    Pagess. 206
    Number of pages1 s.
    Publication formOnline - E
    ActionEFMC International Symposium on Advances in Synthetic and Medicinal Chemistry /6./
    Event date15.11.2015 - 18.11.2015
    VEvent locationRehovot
    CountryIL - Israel
    Event typeWRD
    Languageeng - English
    CountryIL - Israel
    KeywordsCB-DDM ; phosphorium ; ammonium
    Subject RIVCC - Organic Chemistry
    Institutional supportUCHP-M - RVO:67985858
    AnnotationHere we report synthesis of new library of CB-DDM with both ammonium and phosphonium groups on the periphery. To evaluate the effect of substitution of substitution of nitrogen atom by phosphorus we prepared two series of identical CS_DDM in 1st – 3rd generations which differs only in onium groups (N or P). Comparative study of their cytotoxicity, the ability to form dendriplexes and their transfections through cell membrane will be presented. The results are supported by computational modeling.
    WorkplaceInstitute of Chemical Process Fundamentals
    ContactEva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227
    Year of Publishing2016
Počet záznamů: 1  

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