Počet záznamů: 1
Development of gut inflammation in mice colonized with mucosa-associated bacteria from patients with ulcerative colitis
- 1.0457062 - ÚEM 2016 RIV GB eng J - Článek v odborném periodiku
Du, Z. - Hudcovic, T. - Mrázek, J. - Kozáková, H. - Šrůtková, D. - Schwarzer, M. - Tlaskalová-Hogenová, H. - Kostovčík, M. - Kverka, Miloslav
Development of gut inflammation in mice colonized with mucosa-associated bacteria from patients with ulcerative colitis.
Gut Pathogens. Roč. 7, dec 21 (2015), s. 32. ISSN 1757-4749. E-ISSN 1757-4749
Grant CEP: GA MŠMT(CZ) ED1.1.00/02.0109; GA ČR(CZ) GAP303/12/0535
Institucionální podpora: RVO:68378041
Klíčová slova: dysbiosis * microbiota * germ-free mice * ulcerative colitis
Kód oboru RIV: FR - Farmakologie a lékárnická chemie
Impakt faktor: 2.816, rok: 2015
None of the HMA mice developed colitis spontaneously. When treated with DSS, mice in F4 generation of one line of colonized mice (aHMA) developed colitis. Compared to the DSS-resistant earlier generations of aHMA mice, the F4 generation have increased abundance of Clostridium difficile and decrease abundance of C. symbiosum in their cecum contents measured by denaturing gradient gel electrophoresis and DNA sequencing. In our study, mucosa-associated microbes of UC patients were not able to induce spontaneous colitis in gnotobiotic BALB/c mice but they were able to increase the susceptibility to DSS-induced colitis, once the potentially deleterious microbes found a suitable niche.
Trvalý link: http://hdl.handle.net/11104/0257509
Počet záznamů: 1