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Stochastic model explains formation of cell arrays on H/O-diamond patterns
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SYSNO ASEP 0456225 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Stochastic model explains formation of cell arrays on H/O-diamond patterns Tvůrce(i) Ukraintsev, Egor (FZU-D) RID, ORCID
Brož, A. (CZ)
Hubálek Kalbáčová, M. (CZ)
Kromka, Alexander (FZU-D) RID, ORCID, SAI
Rezek, Bohuslav (FZU-D) RID, ORCIDZdroj.dok. Biointerphases. - : AIP Publishing - ISSN 1934-8630
Roč. 10, č. 4 (2015), "041006-1"-"041006-9"Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova cell migration ; biofilm array ; diamond surface ; stochastic simulations Vědní obor RIV BO - Biofyzika CEP GA15-01687S GA ČR - Grantová agentura ČR Institucionální podpora FZU-D - RVO:68378271 UT WOS 000368526400019 EID SCOPUS 84954450635 DOI 10.1116/1.4934794 Anotace Cell migration plays an important role in many biological systems. A relatively simple stochastic model is developed and used to describe cell behavior on chemically patterned substrates. The model is based on three parameters: the speed of cell movement (own and external), the probability of cell adhesion, and the probability of cell division on the substrate. The model is calibrated and validated by experimental data obtained on hydrogen- and oxygen-terminated patterns on diamond. Thereby, the simulations reveal that: i) the difference in the cell movement speed on these surfaces (about 1.5x) is the key factor behind the formation of cell arrays on the patterns, ii) this difference is provided by the presence of fetal bovine serum (validated by experiments), and iii) the directional cell flow promotes the array formation. The model also predicts that the array formation requires mean distance of cell travel at least 10% of intended stripe width. Pracoviště Fyzikální ústav Kontakt Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Rok sběru 2016
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