Počet záznamů: 1
Dendritic high-molecular-weight polymer drug carriers and their conjugates with drugs especially for treatment of solid tumours
- 1.0452672 - ÚMCH 2016 RIV eng P - Patentový dokument
Etrych, Tomáš - Chytil, Petr - Strohalm, Jiří - Ulbrich, Karel - Říhová, Blanka
Dendritic high-molecular-weight polymer drug carriers and their conjugates with drugs especially for treatment of solid tumours.
2015. Vlastník: Ústav makromolekulární chemie AV ČR, v. v. i. - Mikrobiologický ústav AV ČR, v. v. i. Datum udělení patentu: 03.11.2015. Číslo patentu: US9173949
Grant CEP: GA AV ČR IAA400500806; GA AV ČR KAN200200651
Výzkumný záměr: CEZ:AV0Z40500505; CEZ:AV0Z50200510
Klíčová slova: polymer conjugates * doxorubicin * drug targeting
Kód oboru RIV: CD - Makromolekulární chemie; FR - Farmakologie a lékárnická chemie (MBU-M)
http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=9173949&OS=9173949&RS=9173949
The present invention relates to water-soluble high-molecular-weight polymer drug carriers and their conjugates with drugs, derived from dendrimers of the amidoamine and 2,2-bis(hydroxymethyl)propanoic types, the amino and hydroxy end groups of which are attached to semitelechelic copolymers of N-(2 hydroxypropyl)methacrylamide (HPMA) through biodegradable spacers. The polymer carriers and conjugates enable targeted transport notably of anticancer drugs into solid tumors in which biodegradation, the associated controlled drug release and subsequent elimination of polymer carrier from the organism are provided. The polymer carrier conjugated with a cancerostatic for use in targeted therapy of human tumors.
Trvalý link: http://hdl.handle.net/11104/0253919
Počet záznamů: 1