Počet záznamů: 1
Direct One-Pot Synthesis of Nucleosides from Unprotected or 5-O-Monoprotected D-Ribose
- 1.0450014 - ÚOCHB 2016 RIV US eng J - Článek v odborném periodiku
Downey, Alan Michael - Richter, C. - Pohl, Radek - Mahrwald, R. - Hocek, Michal
Direct One-Pot Synthesis of Nucleosides from Unprotected or 5-O-Monoprotected D-Ribose.
Organic Letters. Roč. 17, č. 18 (2015), s. 4604-4607. ISSN 1523-7060. E-ISSN 1523-7052
Grant CEP: GA ČR GAP207/11/0344
Institucionální podpora: RVO:61388963
Klíčová slova: nucleosides * cytostatics * biological activity
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 6.732, rok: 2015
http://pubs.acs.org/doi/pdf/10.1021/acs.orglett.5b02332
New, improved methods to access nucleosides are of general interest not only to organic chemists but to the greater scientific community as a whole due their key implications in life and disease. Current synthetic methods involve multistep procedures employing protected sugars in the glycosylation of nudeobases. Using modified Mitsunobu conditions, we report on the first direct glycosylation of purine and pyrimidine nudeobases with unprotected D-ribose to provide, beta-pyranosyl nucleosides and a one-pot strategy to yield beta-furanosides from the heterocycle and 5-O-monoprotected D-ribose.
Trvalý link: http://hdl.handle.net/11104/0251424
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Počet záznamů: 1