Počet záznamů: 1
Mutation in the Drosophila melanogaster adenosine receptor gene selectively decreases the mosaic hyperplastic epithelial outgrowth rates in wts or dco heterozygous flies
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SYSNO ASEP 0438115 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Mutation in the Drosophila melanogaster adenosine receptor gene selectively decreases the mosaic hyperplastic epithelial outgrowth rates in wts or dco heterozygous flies Tvůrce(i) Sidorov, Roman (BC-A) RID, ORCID
Kučerová, Lucie (BC-A) RID, ORCID
Kiss, I. (HU)
Žurovec, Michal (BC-A) RID, ORCIDCelkový počet autorů 4 Zdroj.dok. Purinergic Signalling - ISSN 1573-9538
Roč. 11, č. 1 (2015), s. 95-105Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova cell competition ; Adgf-A ; Ent2 Vědní obor RIV EB - Genetika a molekulární biologie CEP GA14-27816S GA ČR - Grantová agentura ČR Institucionální podpora BC-A - RVO:60077344 UT WOS 000350883100006 EID SCOPUS 84925535445 DOI https://doi.org/10.1007/s11302-014-9435-2 Anotace Adenosine (Ado) is a purine nucleoside that modulates many physiological processes in the body. It plays a prominent role as a paracrine signal of metabolic imbalance within tissues and serves as a signaling mechanism to coordinate tissue activity. Ado exerts a broad range of cytoprotective, growth-promoting, and immunosuppressive effects and was observed at a high concentration in a number of human tumors, it was therefore suggested to be an important factor regulating tumor growth. We developed a method for the measurement of the Ado effect on tumor growth in/Drosophila melanogaster/using the modification of somatic mutation and recombination test (SMART). In this report, we examined the effect of three/Drosophila/genes involved in Ado signaling on the incidence of somatic mosaic clones, including adenosine receptor (/AdoR/), adenosine transporter (/Ent2/), and adenosine deaminase/Adgf-A/. We show that genetic manipulations with these genes do not affect control clones, but cause dramatic changes in the frequency of hyperplastic clones established by the loss of heterozygosity (LOH) of the/warts/(/wts/) tumor suppressor gene/(wts/homolog in humans is called/LATS1/and its down-regulation has been reported in a number of tumors). The loss of/AdoR/function also decreases the frequency of/dco/tumor clones (human homolog of/dco/is called CK1δ). Our data show that adenosine and/warts/signaling pathways interact and adenosine signaling plays an important role in growth and survival of homozygous/wts^- /cells. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2016 Elektronická adresa http://link.springer.com/article/10.1007%2Fs11302-014-9435-2
Počet záznamů: 1