Počet záznamů: 1
Advances in Biology and Medicine
- 1.
SYSNO ASEP 0436764 Druh ASEP M - Kapitola v monografii Zařazení RIV Záznam nebyl označen do RIV Název Adult Bone Marrow Stem Cells and Biocompatible Polymers in SCI Repair Tvůrce(i) Hejčl, Aleš (UEM-P) RID, ORCID
Jendelová, Pavla (UEM-P) RID, ORCID
Syková, Eva (UEM-P) RIDCelkový počet autorů 3 Zdroj.dok. Advances in Biology and Medicine , Vol. 1. - New York : NOVA SCIENCE PUBLISHERS, 2010 / Berhardt L. V. - ISBN 978-1-60876-863-9 Rozsah stran s. 199-222 Poč.str. 24 s. Poč.str.knihy 460 Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova spinal cord injury ; central nervous system ; stromal cells Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy Institucionální podpora UEM-P - RVO:68378041 UT WOS 000286869700007 Anotace The effects of implanted rat MSCs was compared with the implantation of a freshly prepared mononuclear fraction of bone marrow cells (BMCs) or the injection of granulocyte colony-stimulating factor. Lesioned animals grafted with MSCs, BMCs or treated with G-CSF had significantly smaller lesions and better motor performance. The transplantation of MSCs in animal models of chronic SCI (which result in cavity formation) led to only modest improvement. Autologous BMC implantation was used in a Phase I/II clinical trial in patients with SCI. Intra-arterial vs. intravenous administration and groups of acute vs. chronic patients were compared. Implantation was safe; in addition, 5 out of 6 patients with a subacute cervical lesion improved their function following the administration of BMCs via a. vertebralis. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2015
Počet záznamů: 1