Počet záznamů: 1
Contrasting patterns of polymorphism and selection in bacterial-sensing toll-like receptor 4 in two house mouse subspecies
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SYSNO ASEP 0429660 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Contrasting patterns of polymorphism and selection in bacterial-sensing toll-like receptor 4 in two house mouse subspecies Tvůrce(i) Fornůsková, Alena (UBO-W) RID, SAI, ORCID
Bryja, Josef (UBO-W) RID, SAI, ORCID
Vinkler, M. (CZ)
Macholán, Miloš (UZFG-Y) RID, ORCID
Piálek, Jaroslav (UBO-W) RID, ORCID, SAICelkový počet autorů 5 Zdroj.dok. Ecology and Evolution. - : Wiley - ISSN 2045-7758
Roč. 4, č. 14 (2014), s. 2931-2944Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova adaptive evolution ; arms race ; directional selection ; host–pathogen interaction ; MAMPs ; Mus musculus ; parasite-mediated selection ; pattern-recognition receptors Vědní obor RIV EG - Zoologie CEP GA206/08/0640 GA ČR - Grantová agentura ČR Institucionální podpora UBO-W - RVO:68081766 ; UZFG-Y - RVO:67985904 UT WOS 000340146300010 EID SCOPUS 84904546494 DOI 10.1002/ece3.1137 Anotace Detailed investigation of variation in genes involved in pathogen recognition is crucial for understanding co-evolutionary processes between parasites and their hosts. Triggering immediate innate response to invading microbes, Toll-like receptors (TLRs) belong presently among the best-studied receptors of vertebrate immunity. TLRs exhibit remarkable interspecific variation and also intraspecific polymorphism is well documented. In humans and laboratory mice, several studies have recently shown that single amino acid substitution may significantly alter receptor function. Unfortunately, data concerning polymorphism in free-living species are still surprisingly scarce. In this study, we analyzed the polymorphism of Toll-like receptor 4 (Tlr4) over the Palearctic range of house mouse (Mus musculus). Our results reveal contrasting evolutionary patterns between the two recently (0.5 million years ago) diverged house mouse subspecies: M. m. domesticus (Mmd) and M. m. musculus (Mmm). Comparison with cytochrome b indicates strong directional selection in Mmd Tlr4. Throughout the whole Mmd western Palaearctic region, a single variant of the ligand-binding region is spread, encoded mainly by one dominant haplotype (71% of Mmd). In contrast, Tlr4 in Mmm is much more polymorphic with several haplotypes at intermediate frequencies. Moreover, we also found clear signals of recombination between two principal haplogroups in Mmm, and we identified eight sites under positive selection in our dataset. Our results suggest that observed differences in Tlr4 diversity may be attributed to contrasting parasite-mediated selection acting in the two subspecies. Pracoviště Ústav biologie obratlovců Kontakt Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Rok sběru 2015
Počet záznamů: 1