Počet záznamů: 1
Synthesis of Novel N-Branched Acyclic Nucleoside Phosphonates As Potent and Selective Inhibitors of Human, Plasmodium falciparum and Plasmodium vivax 6-Oxopurine Phosphoribosyltransferases
- 1.0378633 - ÚOCHB 2013 RIV US eng J - Článek v odborném periodiku
Hocková, Dana - Keough, D. T. - Janeba, Zlatko - Wang, T. - de Jersey, J. - Guddat, L. W.
Synthesis of Novel N-Branched Acyclic Nucleoside Phosphonates As Potent and Selective Inhibitors of Human, Plasmodium falciparum and Plasmodium vivax 6-Oxopurine Phosphoribosyltransferases.
Journal of Medicinal Chemistry. Roč. 55, č. 13 (2012), s. 6209-6223. ISSN 0022-2623. E-ISSN 1520-4804
Grant CEP: GA ČR GAP207/11/0108; GA MŠMT 1M0508
Grant ostatní: NHMRC(AU) 569703; NHMRC(AU) 1030353
Institucionální podpora: RVO:61388963
Klíčová slova: enzyme inhibitors * aza-ANPs * malaria
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 5.614, rok: 2012
Series of novel acyclic nucleoside phosphonates - aza-ANPs - was designed as potent and selective inhibitors of 6-oxopurine phosphoribosyltransferases, crucial enzyme for the survival of malarial parasites.
Trvalý link: http://hdl.handle.net/11104/0210055
Počet záznamů: 1