Počet záznamů: 1
Dual effect of lobeline on alpha 4 beta 2 rat neuronal nicotinic receptors
- 1.0372065 - FGÚ 2012 RIV NL eng J - Článek v odborném periodiku
Kaniaková, Martina - Lindovský, Jiří - Krůšek, Jan - Adámek, S. - Vyskočil, František
Dual effect of lobeline on alpha 4 beta 2 rat neuronal nicotinic receptors.
European Journal of Pharmacology. Roč. 658, 2-3 (2011), s. 108-113. ISSN 0014-2999. E-ISSN 1879-0712
Grant CEP: GA ČR(CZ) GA202/09/0806; GA AV ČR(CZ) IAA500110905; GA MŠMT(CZ) LC554
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: lobeline * nicotinic acetylcholine receptor
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 2.516, rok: 2011
The effect of lobeline on rat alpha 4 beta 2 nicotinic receptors expressed in COS cells was studied using the patch-clamp technique. We found that the effect of lobeline is complex and varies with applied concentration and the application scheme. The causes of the variable lobeline manifestation (potentiation, inhibition) are different binding and unbinding rates and differences in the affinity of lobeline to individual functional states of nicotinic receptors
Trvalý link: http://hdl.handle.net/11104/0205459
Počet záznamů: 1