Počet záznamů: 1
pH-sensitive polymeric conjugates of an anthracycline cancerostatic drug for targeted therapy
- 1.0369686 - ÚMCH 2012 US eng P - Patentový dokument
Ulbrich, Karel - Etrych, Tomáš - Říhová, Blanka - Jelínková, Markéta - Kovář, Marek
pH-sensitive polymeric conjugates of an anthracycline cancerostatic drug for targeted therapy.
Alexandria: United States Patent and Trademark Office, 2011. Vlastník: Zentiva, k. s. Datum udělení patentu: 05.04.2011. Číslo patentu: US7919076
Výzkumný záměr: CEZ:AV0Z40500505; CEZ:AV0Z50200510
Klíčová slova: cancerostatics * polymer cojugates * targeted therapy
Kód oboru RIV: CC - Organická chemie
http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7919076&OS=7919076&RS=7919076
Conjugates consisting of a polymeric carrier constituted by 30 to 3,000 monomer units linked to form a polymeric chain, composed of a) 60 to 99% of N-(2-hydroxypropyl)methacrylamide units, b) 1 to 25% of units of methacryloylated hydrazones of .alpha.-amino acids, .epsilon.-amino acids, aromatic amino acids or oligopeptides terminated with a molecule of an anthracycline cancerostatic, c) 0.5 to 15% of units of methacryloylated .alpha.-amino acids, .epsilon.-amino acids, aromatic amino acids or oligopeptides or their sodium salts.
Trvalý link: http://hdl.handle.net/11104/0203694
Počet záznamů: 1