Počet záznamů: 1
How to asses, visualize and compare the anisotropy of linear structures reconstructed from optical sections ? A study based on histopathological quantification of human brain microvessels
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SYSNO ASEP 0365082 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název How to asses, visualize and compare the anisotropy of linear structures reconstructed from optical sections ? A study based on histopathological quantification of human brain microvessels Tvůrce(i) Kochová, P. (CZ)
Cimrman, R. (CZ)
Janáček, Jiří (FGU-C) RID, ORCID
Witter, K. (AT)
Tonar, Z. (CZ)Zdroj.dok. Journal of Theoretical Biology. - : Elsevier - ISSN 0022-5193
Roč. 286, - (2011), s. 67-78Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova rose of directions ; preferential directions ; chi-square test ; length density ; python Vědní obor RIV EA - Morfologické obory a cytologie CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000294975800008 DOI 10.1016/j.jtbi.2011.07.004 Anotace In our study, we present a novel p(chi2) (chi-square) method for evaluating the anisotropy of line systems that involves comparing the observed length densities of lines with the discrete uniform distribution of an isotropic line system with the chi2-test. Using this method in our open source software, we determined the rose of directions, preferential directions and level of anisotropy of linear systems representing the microscopic blood vessels in samples of various regions from human brains (cortex, subcortical gray matter and white matter). The novel method was compared with two other methods used for anisotropy quantification (ellipsoidal and fractional anisotropy). All three methods detected different levels of anisotropy of blood microvessels in human brain. The microvascular bed in the cortex was closer to an isotropic network, while the microvessels supplying the white matter appeared to be an anisotropic and direction-sensitive system Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2012
Počet záznamů: 1