Počet záznamů: 1
The Synthesis and Conformation of Dihydroxypiperidinyl Derivates of Nucleobases as Novel Iminosugar Nucleoside Analogs
- 1.0359047 - ÚOCHB 2012 RIV DE eng J - Článek v odborném periodiku
Rejman, Dominik - Pohl, Radek - Dračínský, Martin
The Synthesis and Conformation of Dihydroxypiperidinyl Derivates of Nucleobases as Novel Iminosugar Nucleoside Analogs.
European Journal of Organic Chemistry. -, č. 11 (2011), s. 2172-2187. ISSN 1434-193X. E-ISSN 1099-0690
Grant CEP: GA MŠMT(CZ) LC06077; GA MŠMT 2B06065; GA AV ČR KJB400550903
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: iminosugars * azanucleosides * nucleosides
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 3.329, rok: 2011
An optimized method for the synthesis of an important chiral scaffold, was developed. Using this intermediate, the preparation of various chiral aminodihydroxypiperidines and their transformation into a series of non-glycosidic, six-membered azanucleosides was accomplished. NMR conformation analysis of the prepared piperidine azanucleosides revealed a preference for the chair conformation, with the nucleobase fixed in the equatorial position in all cases.
Trvalý link: http://hdl.handle.net/11104/0196920
Počet záznamů: 1