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Quality control of no-carrier-added (YCl3)-Y-90 by estimating the labeling efficiency using its reaction with DOTATOC
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SYSNO ASEP 0358999 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Quality control of no-carrier-added (YCl3)-Y-90 by estimating the labeling efficiency using its reaction with DOTATOC Překlad názvu Kontrola kvality nenosičově přidaného (YCl3)-Y-90 určením efektivity značení pomocí jeho reakce s DOTATOC Tvůrce(i) Eigner-Henke, Kateřina (UJF-V) RID
Beran, Miloš (UJF-V)
Šrank, Jiří (UJF-V) RID
Melichar, František (UJF-V) RIDZdroj.dok. Journal of Radioanalytical and Nuclear Chemistry. - : Springer - ISSN 0236-5731
Roč. 278, č. 1 (2008), s. 25-29Poč.str. 5 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova TERNARY COMPLEX-FORMATION ; NEUROENDOCRINE TUMORS ; SOMATOSTATIN ANALOGS Vědní obor RIV FR - Farmakologie a lékárnická chemie CEP FT-TA2/081 GA MPO - Ministerstvo průmyslu a obchodu CEZ AV0Z10480505 - UJF-V (2005-2011) UT WOS 000259863400004 DOI 10.1007/s10967-007-7186-z Anotace The (YCl3)-Y-90 radionuclide precursor (solution of Y-90(3+) in diluted HCl) of high purity and high specific activity is already commercially produced and successfully used in nuclear medicine. At the Nuclear Physics Institute ASCR, the (YCl3)-Y-90 radionuclide precursor is prepared using extraction (SrY)-Sr-90-Y-90 generator (technology of centrifuge extractors with di-2-ethylhexylphosphoric acid, D2EHPA).(1) Its radionuclidic, radiochemical, and chemical purity were examined and specified. The procedure developed for labeling of DOTA-Tyr(3)-octreotide (DOTATOC) with carrier-free Y-86/90 by ROSCH2 at the Institute of Nuclear Chemistry of the University Mainz was optimized and modified in our Department of Radiopharmaceuticals at NPI ASCR as standard labeling test (SLT) for analytical purposes. The SLT as a method for (YCl3)-Y-90 radionuclide precursor quality control determining its labeling efficiency using ITLC SG chromatography is described and proposed thereinafter. Pracoviště Ústav jaderné fyziky Kontakt Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228 Rok sběru 2011
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