Počet záznamů: 1
Increased extracellular adenosine in Drosophila that are deficient in adenosine deaminase activates a release of energy stores leading to wasting and death
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SYSNO ASEP 0356581 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Increased extracellular adenosine in Drosophila that are deficient in adenosine deaminase activates a release of energy stores leading to wasting and death Tvůrce(i) Zuberová, M. (CZ)
Fencková, M. (CZ)
Šimek, Petr (BC-A) RID, ORCID
Janečková, L. (CZ)
Doležal, T. (CZ)Celkový počet autorů 5 Zdroj.dok. Disease Models & Mechanisms. - : Company of Biologists - ISSN 1754-8403
Roč. 3, 11/12 (2010), s. 773-784Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova central nervous system ; glycogen phosphorylase ; immune response Vědní obor RIV CE - Biochemie CEP GD204/09/H058 GA ČR - Grantová agentura ČR CEZ AV0Z50070508 - ENTU-I, BC-A (2005-2011) UT WOS 000284061000021 DOI 10.1242/dmm.005389 Anotace Extracellular adenosine is an important signaling molecule in neuromodulation, immunomodulation and hypoxia. Adenosine dysregulation can cause various pathologies, exemplified by a deficiency in adenosine deaminase in severe combined immunodeficiency. We have established a Drosophila model to study the effects of increased adenosine in vivo by mutating the main Drosophila adenosine deaminase-related growth factor (ADGF-A). Using a genetic screen, we show here that the increased extracellular adenosine in the adgf-a mutant is associated with hyperglycemia and impairment in energy storage. The adenosine works in this regard through the adenosine receptor as an anti-insulin hormone in parallel to adipokinetic hormone, a glucagon counterpart in flies. If not regulated properly, this action can lead to a loss of energy reserves (wasting) and death of the organism. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2011
Počet záznamů: 1