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Characterization of Lymphocyte Subsets in Patients with Common Variable Immunodeficiency Reveals Subsets of Naive Human B Cells Marked by CD24 Expression
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SYSNO ASEP 0355461 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Characterization of Lymphocyte Subsets in Patients with Common Variable Immunodeficiency Reveals Subsets of Naive Human B Cells Marked by CD24 Expression Tvůrce(i) Vlková, M. (CZ)
Froňková, E. (CZ)
Kanderová, V. (CZ)
Janda, A. (CZ)
Růžičková, Šárka (BTO-N) RID
Litzman, J. (CZ)
Šedivá, A. (CZ)
Kalina, T. (CZ)Zdroj.dok. Journal of Immunology. - : American Association of Immunologists - ISSN 0022-1767
Roč. 185, č. 11 (2010), s. 6431-6438Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova B lymphocyte immunophenotyping ; naive B cells ; common variable immunodeficiency Vědní obor RIV EC - Imunologie CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000284311500007 DOI 10.4049/jimmunol.0903876 Anotace B cells from 48 patients with CVID and 49 healthy controls were analyzed by polychromatic flow cytometry to examine phenotype. We have described two groups of patients with normal (CVID-21norm) or increased (CVID-21lo) proportions of CD27(neg)CD21(neg)CD38(neg) B cells. Upon further analyses, we found two discrete subpopulations of this subset based on the expression of CD24. The B cell subsets showed a markedly increased proliferation in CVID-21lo patients as compared with healthy controls, suggesting developmental arrest rather than increased bone marrow output. In additon, two different subpopulations based on IgM and CD24 expression were found corresponding to follicular (FO) I and FO II cells previously described in mice. We propose that the CD27(neg)CD21(neg)CD38(neg) B cells increased in some of the CVID patients originate from the two FO subsets after loss of CD21 expression Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2011
Počet záznamů: 1