Počet záznamů: 1
Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione
- 1.0353777 - BFÚ 2011 RIV US eng J - Článek v odborném periodiku
Kostrhunová, Hana - Kašpárková, Jana - Gibson, D. - Brabec, Viktor
Studies on cellular accumulation of satraplatin and its major metabolite JM118 and their interactions with glutathione.
Molecular Pharmaceutics. Roč. 7, č. 6 (2010), s. 2093-2102. ISSN 1543-8384. E-ISSN 1543-8392
Grant CEP: GA MŠMT(CZ) ME08017; GA MŠMT(CZ) ME10066; GA MŠMT(CZ) OC08003; GA AV ČR(CZ) IAA400040803; GA ČR(CZ) GAP301/10/0598
Grant ostatní: GA MŠk(CZ) LC06030; GA AV ČR(CZ) KAN200200651
Program: LC; KA
Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Klíčová slova: JM118 * cellular accumulation * glutathione
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 5.400, rok: 2010
The organic cation transporters play a more important role in the mechanism of cytotoxicity of JM118 than in the cytotoxicity of cisplatin. Satraplatin is a poor substrate of these transporters. Satraplatin reacts with glutathione with the rate markedly lower than JM118 and cisplatin. Satraplatin can be activated by glutathione allowing it to react with DNA.
Trvalý link: http://hdl.handle.net/11104/0006241
Počet záznamů: 1