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Steroid conjugates: Synthesis and preliminary biological testing of pro-juvenoids
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SYSNO ASEP 0349942 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Steroid conjugates: Synthesis and preliminary biological testing of pro-juvenoids Tvůrce(i) Svobodová, Hana (UEB-Q)
Ryšavá, Hana (UEB-Q)
Pavlík, Milan (UEB-Q) RID, ORCID
Šaman, David (UOCHB-X) RID, ORCID
Drašar, Pavel (UOCHB-X)
Wimmer, Zdeněk (UEB-Q) RID, ORCIDZdroj.dok. Bioorganic & Medicinal Chemistry. - : Elsevier - ISSN 0968-0896
Roč. 18, č. 23 (2010), s. 8194-8203Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Pyrrhocoris apterus ; Structure–activity relationship ; Juvenoid Vědní obor RIV CC - Organická chemie CEP 2B06024 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z50380511 - UEB-Q (2005-2011) AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000284059500008 DOI 10.1016/j.bmc.2010.10.013 Anotace A series of 10 new pro-juvenoids (juvenogens, insect hormonogenic compounds, pro-drug-like agents) was synthesized using isomeric synthetic juvenoids (insect juvenile hormone analogs) and steroid molecules as patterns modifying parts of the complex hormonogenic molecules. In addition, several new synthons were prepared, which were required by the designed synthetic protocol to achieve the target molecules. These pro-juvenoids were subjected to the topical screening tests and to the drinking assays on the red firebug (Pyrrhocoris apterus), a convenient model laboratory phytophagous insect. Simple and efficient synthetic procedures for the preparation of the target pro-juvenoids and their synthons are presented. Furthermore, the biological activity of the pro-juvenoids in comparison with the activity of their parent juvenoids and that of several commercially available agents is demonstrated. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2011
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