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Lyophilised liposome-based formulations of alpha-tocopheryl succinate: preparation and physico-chemical characterisation
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SYSNO ASEP 0349342 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Lyophilised liposome-based formulations of alpha-tocopheryl succinate: preparation and physico-chemical characterisation Tvůrce(i) Koudelka, S. (CZ)
Mašek, J. (CZ)
Neužil, Jiří (BTO-N) RID
Turánek, J. (CZ)Zdroj.dok. Journal of Pharmaceutical Sciences - ISSN 0022-3549
Roč. 99, č. 5 (2010), s. 2434-2443Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Vitamin E analogues ; liposome ; cancer Vědní obor RIV FR - Farmakologie a lékárnická chemie CEP KAN200520703 GA AV ČR - Akademie věd CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000277132500020 DOI 10.1002/jps.22002 Anotace alpha-Tocopheryl succinate (alpha-TOS) is a semisynthetic analogue of alpha-tocopherol with selective toxicity to the cancer cells and anticancer activity in vivo. Yet, no suitable formulation of alpha-TOS for medical application has been reported. Various formulations, for example, solutions in organic solvents, oil emulsions and vesicules prepared by spontaneous vesiculation, polyethylene glycol conjugates and liposomes of various compositions have been tested. We developed and characterised a stable lyophilised liposome-based alpha-TOS formulation. alpha-TOS (15 mol%) was incorporated into large oligolamellar vesicles (OLVs) composed of soy phosphatidylcholine (SPC) by the method of lipid film hydration followed by extrusion through polycarbonate filters. The data indicate good physical and chemical stability of the lyophilised preparation of alpha-TOS liposomes that can be used in clinical medicine Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2011
Počet záznamů: 1