Počet záznamů: 1
An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part II: oxidative damage to DNA
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SYSNO ASEP 0347658 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part II: oxidative damage to DNA Tvůrce(i) Rössner ml., Pavel (UEM-P) RID, ORCID
Topinka, Jan (UEM-P) RID, ORCID
Hovorka, J. (CZ)
Milcová, Alena (UEM-P)
Schmuczerová, Jana (UEM-P) RID
Kroužek, J. (CZ)
Šrám, Radim (UEM-P) RIDZdroj.dok. Toxicology Letters. - : Elsevier - ISSN 0378-4274
Roč. 198, č. 3 (2010), s. 312-316Poč.str. 5 s. Jazyk dok. eng - angličtina Země vyd. IE - Irsko Klíč. slova air pollution ; particulate matter ; atmospheric aerosol Vědní obor RIV DN - Vliv životního prostředí na zdraví CEP 2B08005 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000282855300003 EID SCOPUS 79954615889 DOI 10.1016/j.toxlet.2010.06.021 Anotace The study investigated the ability of organic extracts of size segregated aerosol particles-PM (EOM; three size fractions ranging from 0.17 to 10µm and collected in 4 localities differing in the extent of pollution) to induce oxidative damage to DNA in an acellular system of calf thymus DNA with/without metabolic activation. It was found that levels of 8-oxodG tended to increase with decreasing sizes of PM; metabolic activation increased the oxidative capacity of PM. A significant positive association between concentrations of c-PAHs bound to PM and levels of 8-oxodG after metabolic activation of EOM samples was observed. The correlation was weaker and non-significant for samples without metabolic activation. It may be concluded that organic extracts of PM were able to induce oxidative damage to DNA in vitro; this ability was increased after S9 metabolic activation of EOM and with decreasing sizes of PM. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2011
Počet záznamů: 1