Počet záznamů: 1
Associations between Polycyclic Aromatic Hydrocarbon-Related Exposures and p53 Mutations in Breast Tumors
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SYSNO ASEP 0347653 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Associations between Polycyclic Aromatic Hydrocarbon-Related Exposures and p53 Mutations in Breast Tumors Tvůrce(i) Mordukhovich, I. (US)
Rössner ml., Pavel (UEM-P) RID, ORCID
Terry, M. B. (US)
Santella, R. (US)
Zhang, Y.J. (US)
Hibshoosh, H. (US)
Memeo, L. (IT)
Mansukhani, M. (US)
Long, CH.M. (US)
Garbowski, G. (US)
Agrawal, M. (US)
Gaudet, M. M. (US)
Steck, S. E. (US)
Sagiv, S. K. (US)
Eng, S. M. (US)
Teitelbaum, S. L. (US)
Neugut, A. I. (US)
Conway-Dorsey, K. (US)
Gammon, M. D. (US)Zdroj.dok. Environmental Health Perspectives. - : U.S. Department of Health and Human Services - ISSN 0091-6765
Roč. 118, č. 4 (2010), s. 511-518Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova breast cancer ; p53 mutation ; p53 overexpression Vědní obor RIV DN - Vliv životního prostředí na zdraví CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000276454800024 EID SCOPUS 77951675375 DOI 10.1289/ehp.0901233 Anotace The study tested the hypothesis that associations of PAH-related exposures with breast cancer differ according to tumor p53 mutation status, effect, type, and number. This possibility was examined in a population-based case-control study where p53 mutations in 859 tumors were detected. Participants with p53 mutations were less likely to be exposed to polycyclic aromatic hydrocarbons (PAHs) than participants without mutations. In conclusion, the study suggests that PAHs may be associated with specific breast tumor p53 mutation subgroup rather than with overall p53 mutations and may be related to breast cancer through mechanisms other than p53 mutation. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2011
Počet záznamů: 1