Počet záznamů: 1
The potential of the cruciform structure formation as an important factor influencing p53 sequence-specific binding to natural DNA targets
- 1.0340614 - BFÚ 2010 RIV GB eng J - Článek v odborném periodiku
Brázdová Jagelská, Eva - Pivoňková, Hana - Fojta, Miroslav - Brázda, Václav
The potential of the cruciform structure formation as an important factor influencing p53 sequence-specific binding to natural DNA targets.
Biochemical and Biophysical Research Communications. Roč. 391, č. 3 (2010), s. 1409-1414. ISSN 0006-291X. E-ISSN 1090-2104
Grant CEP: GA ČR(CZ) GP301/07/P160; GA ČR(CZ) GP204/07/P476; GA AV ČR(CZ) IAA500040701
Grant ostatní: GA ČR(CZ) GA301/10/1211
Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Klíčová slova: scDNA * plasmid pBluescript SK * linear DNA
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 2.595, rok: 2010
P53 binding to DNA is strongly influenced by DNA topology. We investigated the cruciform structure formation of various inverted repeats in p53-responsive sequences from p21, RGC, mdm2 and GAAD45 promoters under negative superhelical stress and analyzed the effects of these DNA topology changes on p53-DNA binding.
Trvalý link: http://hdl.handle.net/11104/0183823
Počet záznamů: 1