Počet záznamů: 1
Current and Novel Inhibitors of HIV Protease
- 1.0336551 - ÚOCHB 2011 RIV CH eng J - Článek v odborném periodiku
Pokorná, Jana - Machala, L. - Řezáčová, Pavlína - Konvalinka, Jan
Current and Novel Inhibitors of HIV Protease.
Viruses. Roč. 1, č. 3 (2009), s. 1209-1239. ISSN 1999-4915. E-ISSN 1999-4915
Grant CEP: GA MŠMT 1M0508
Grant ostatní: GA AV ČR(CZ) IAAX00320901
Program: IA
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: HIV protease * protease inhibitor * HAART
Kód oboru RIV: CE - Biochemie
This review describes all nine currently available FDA-approved protease inhibitors, discusses their pharmacokinetic properties, off-target activities, side-effects, and resistance profiles. The compounds in the various stages of clinical development are also introduced, as well as alternative approaches, aiming at other functional domains of HIV PR. The potential of these novel compounds to open new way to the rational drug design of human viruses is critically assessed.
Trvalý link: http://hdl.handle.net/11104/0180760
Počet záznamů: 1