- Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new …
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Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase

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    0329066 - ÚOCHB 2010 RIV GB eng J - Journal Article
    Hocková, Dana - Holý, Antonín - Masojídková, Milena - Keough, D. T. - de Jersey, J. - Guddat, L. W.
    Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.
    Bioorganic & Medicinal Chemistry. Roč. 17, č. 17 (2009), s. 6218-6232. ISSN 0968-0896. E-ISSN 1464-3391
    R&D Projects: GA MŠMT 1M0508; GA AV ČR 1QS400550501
    Institutional research plan: CEZ:AV0Z40550506
    Keywords : acyclic nucleoside phosphonates * drug design * phosphoribosyltransferase * enzyme inhibitors * purine salvage pathway
    Subject RIV: CC - Organic Chemistry
    Impact factor: 2.822, year: 2009 ; AIS: 0.702, rok: 2009
    DOI: https://doi.org/10.1016/j.bmc.2009.07.044
    Permanent Link: http://hdl.handle.net/11104/0175201
     
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