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MMP19 is essential for T cell development and T cell-mediated cutaneous immune responses
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SYSNO ASEP 0311095 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název MMP19 is essential for T cell development and T cell-mediated cutaneous immune responses Překlad názvu MMP19 je nezbytná pro vývoj T buněk a pro imunitní odpoveď kůže zprostředkovanou T buňkami Tvůrce(i) Beck, Inken (UMG-J) RID
Ruckert, R. (DE)
Brandt, K. (DE)
Mueller, M.S. (CH)
Sadowski, T. (DE)
Brauer, R. (DE)
Schirmacher, P. (DE)
Mentlein, R. (DE)
Sedláček, Radislav (UMG-J) RIDZdroj.dok. PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 3, č. 6 (2008), e2343-e2343Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova matrix metalloproteinase ; T cell ; immune response Vědní obor RIV EB - Genetika a molekulární biologie CEZ AV0Z50520514 - UMG-J (2005-2011) AV0Z50520701 - BTO-N (2007-2013) Anotace MMP19 affects cell proliferation, adhesion and migration but its physiological role is unclear. To determine the role of MMP19 in vivo we generated MMP19-deficient mice. In a contact hypersensitivity model these mice showed impaired T cell-mediated immune reaction characterized by limited influx of inflammatory cells, low proliferation of keratinocytes and reduced number of activated CD8+ T cells in draining lymph nodes. In the inflamed tissue the low number of CD8+ T cells in MMP19-deficient mice correlated with low amounts of proinflammatory cytokines (lymphotactin, I-TAC). T cell populations in the blood of immature, unsensitized mice were diminished due to an altered maturation of thymocytes. In the thymus thymocytes exhibited low proliferation rates and the number of CD4+CD8+ double-positive cells was strongly augmented. Based on the phenotype of MMP19-deficient mice we propose that MMP19 is an important factor in cutaneous immune responses and influences T cell development. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2009
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