P-selectin glycoprotein ligand-1 and E-selectin ligand-1 are differentially modified by fucosyltransferases Fuc-TIV and Fuc-TVII in mouse neutrophils
1.
SYSNO ASEP
0191184
Druh ASEP
J - Článek v odborném periodiku
Zařazení RIV
J - Článek v odborném periodiku
Poddruh J
Ostatní články
Název
P-selectin glycoprotein ligand-1 and E-selectin ligand-1 are differentially modified by fucosyltransferases Fuc-TIV and Fuc-TVII in mouse neutrophils
Tvůrce(i)
Huang, M. Ch. (DE) Zollner, O. (DE) Moll, T. (DE) Malý, Petr (UMG-J) Thall, A. D. (US) Lowe, J. B. (US) Vestweber, D. (DE)
Zdroj.dok.
Journal of Biological Chemistry. - : Elsevier
- ISSN 0021-9258
Roč. 275, č. 40 (2000), s. 31353-31360
Poč.str.
8 s.
Jazyk dok.
eng - angličtina
Země vyd.
US - Spojené státy americké
Vědní obor RIV
EB - Genetika a molekulární biologie
CEZ
AV0Z5052915 - UMG-J
Anotace
We used mice deficient in Fuc-TIV and/or Fuc-TVII to examinehow these enzymes generate selectin-binding glycoforms of PSGL-1 and ESL-1 in mouse neutrophils using recombinant antibody-like forms of the respective endothelial selectins. Our data imply that in mouse neutrophils and their precursors, Fuc-TVII exclusively directs expression of PSGL-1 glycoforms bound with high affinity by P-selectin, while Fuc-TIV preferentially directs expression of ESL-1 glycoforms that exhibit high affinity for E-selectin.
