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Immunological aspects of people working under exposure to pesticides
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SYSNO ASEP 0185028 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název Immunological aspects of people working under exposure to pesticides Tvůrce(i) Borská, L. (CZ)
Andrýs, C. (CZ)
Fiala, Z. (CZ)
Tejral, J. (CZ)
Bencko, V. (CZ)
Kučera, Jan (UJF-V) RID, ORCID, SAIZdroj.dok. Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 49, - (2000), s. P32Poč.str. 1 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Vědní obor RIV BG - Jaderná, atomová a mol. fyzika, urychlovače CEZ AV0Z1048901 - UJF-V Anotace Around the world, millions of people are exposed to pesticides at work and/or in their home. Pesticides have been reported as altering immune functions in animals and humans (depressed humoral and cellular responses). Blood samples weretaken from the group of 19 people working in agriculture (average age 45.5 years, 47 smokers). Values found in peopleworking in agriculture exposed group were compared with those of control represented by laboratory group (laboratory reference levels obtained from healthy blood donors of the same age and sex). From people working in agriculture we recorded a number of changes in immunological parameters, whencompared with laboratory control group in the humoral responses a significant IgM and IgA decrease appeared from people working in agriculture when compared with controls. In turn we recorded a marked increase of C3 complement componentin the case of exposed group. Significant alterations were registered in "acute" reactants (alpha-1-antitrypsin, alpha-2-macroglobulin, ceruloplasmim, orosmucoid, haptoglobin,c-reactive protein, transferin) too. In the cellular responses asignificant beta-2-microglobulin decrease appeared in peopleworking in agriculture when compared with controls. Significant reduction of a number of phagocytosis capable cells wasnot found. From all the stated data it follows that immunological parameters may represent sensitive markers of health status. Pracoviště Ústav jaderné fyziky Kontakt Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228 Rok sběru 2001
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