0173860 - UEM-P 20043003 RIV US eng J - Článek v odborném periodiku
Peterková, Renata - Peterka, Miroslav - Lesot, H.
The Developing Mouse Dentition - a new tool for apoptosis study.
New York Academy of Sciences. Annals. Roč. 1010, - (2003), s. 453-466. ISSN 0077-8923. E-ISSN 1749-6632
Grant CEP: GA ČR GA304/02/0448
Výzkumný záměr: CEZ:AV0Z5039906
Klíčová slova: apoptosis, tooth
Kód oboru RIV: EA - Morfologické obory a cytologie
Impakt faktor: 1.892, rok: 2003

We proposed a hypothesis to explain the stimulation of apoptosis in the dental epithelium by integrating two concepts:(1) The regulation of epithelial bidding by positional information generated from interactions between growth-activating and growth-inhibiting signals, and (2) apoptosis stimulation by the failure of death-suppressing signals. During the budding of the dental epithelium, local excess in growth inhibitors (e.g.,Bmps)might lead to the epithelial cells' failure to receive adequate growth-activating (apoptosis-suppressing) signals. The resulting signal imbalance leads to cell suicide by apoptosis. Understanding of apoptosis regulation in the vestigial tooth primordia can help to elucidate the mechanism of their suppression during evolution and to identify factors essential for tooth survival. The latter knowledge will be important for developing a technology of tooth engineering.
Trvalý link: http://hdl.handle.net/11104/0070886