Cyclin D-cdk6 complex is targeted by p21WAF in growth-arrested lymphoma cells
1.
SYSNO ASEP
0173635
Druh ASEP
J - Článek v odborném periodiku
Zařazení RIV
J - Článek v odborném periodiku
Poddruh J
Ostatní články
Název
Cyclin D-cdk6 complex is targeted by p21WAF in growth-arrested lymphoma cells
Tvůrce(i)
Tvrdík, Daniel (UEM-P) Djaborkhel, Rashed (UEM-P) Nagy, Alexandr (UEM-P) Eckschlager, T. (CZ) Raška, Ivan (UEM-P) Müller, Julius (UEM-P)
Zdroj.dok.
Journal of Structural Biology. - : Elsevier
- ISSN 1047-8477
Roč. 140, - (2002), s. 49-56
Poč.str.
8 s.
Jazyk dok.
eng - angličtina
Země vyd.
US - Spojené státy americké
Klíč. slova
cyclin-dependent kinase ; follicular lymphoma ; retinoblastoma protein
Vědní obor RIV
EA - Morfologické obory a cytologie
CEP
GA304/01/0564 GA ČR - Grantová agentura ČR
CEZ
AV0Z5039906 - UEM-P
MSM 111100003
Anotace
The kinase activity of cdk2, cdk4, and cdk6 was significantly reduced and hypophosphorylation of pRb on serine 795 (S795) and threonine 373 (T373) was observed. Both cdk4 and cdk6 were notably dissociated from cyclin D co-factors, while cyclin E-cdk2 complexes remained coupled in TGFß1-treated cells. TGFß1-induced growth arrest was associated with notably increased binding of p21WAF1 to cdk4 and cdk6.
