Chemical Probes in Biology. Science at the Interface of Chemistry, Biology and Medicine. NATO Science Series, II. Mathematics, Physics and Chemistry, Vol. 129
1.
SYSNO ASEP
0162527
Druh ASEP
M - Kapitola v monografii
Zařazení RIV
C - Kapitola v knize
Název
Quaternary benzo[c]phenanthridine alkaloids biological activities.Intracellular targets of their action and application in human and veterinary medicine
Tvůrce(i)
Šimánek, V. (CZ) Vespalec, Radim (UIACH-O) Šedo, A. (CZ) Ulrichová, J. (CZ) Vičar, J. (CZ)
Zdroj.dok.
Chemical Probes in Biology. Science at the Interface of Chemistry, Biology and Medicine. NATO Science Series, II. Mathematics, Physics and Chemistry, Vol. 129 / Schneider M. P.. - Dordrecht : Kluwer Academic Publishers, 2003
- ISBN 1-4020-1769-3
The article briefly reviewes information on the occurence of of benzo[c]phenanthridine alkaloids (QBA) in plats and on their chemical properties important from the viewpoint of QBA biological and biochemical activities. Than recent results of investigation of authors on QBA are presented: 1. Identification of chemical forms of sanguinarine and cheleryhtrine that complex with mercapto nuclophiles and the determination of stability constants that characterize their binding with human serum albumin;2. Inhibition effects of sanguinarine, cheleryhtrine and fagaronine on DPP-IV-like enzymes isolated from blood plasma and human and rat glinoma cell lines; and 3. QBA role in the genesis of epidemic dropsy syndrome.
