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Transgenic expression of CD36 in the spontaneously hypertensive rat is associated with amelioration of metabolic disturbances but has no effect on hypertension
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SYSNO ASEP 0142552 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Transgenic expression of CD36 in the spontaneously hypertensive rat is associated with amelioration of metabolic disturbances but has no effect on hypertension Author(s) Pravenec, Michal (FGU-C) RID, ORCID
Landa, Vladimír (FGU-C) RID
Zídek, Václav (FGU-C) RID
Musilová, Alena (FGU-C)
Kazdová, L. (CZ)
Qi, N. (US)
Wang, J. (US)
St. Lezin, E. S. (US)
Kurtz, T. W. (US)Source Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 52, č. 6 (2003), s. 681-688Number of pages 8 s. Language eng - English Country CZ - Czech Republic Keywords Cd36 ; dyslipidemia ; transgenic SHR Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA305/00/1646 GA ČR - Czech Science Foundation (CSF) GA301/00/1636 GA ČR - Czech Science Foundation (CSF) NB4904 GA MZd - Ministry of Health (MZ) CEZ AV0Z5011922 - FGU-C Annotation Transgenic expression of Cd36 in the new lines was associated with significantly decreased serum fatty acids, amelioration of insulin resistance and glucose intolerance but failed to induce any consistent changes in blood pressure as measured by radiotelemetry. The current findings confirm the genetic association of defective Cd36 with disordered insulin action and fatty acid metabolism in the SHR/NIH strain and suggest that Cd36 is linked to other gene(s) on rat chromosome 4 that regulate blood pressure. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2004
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