Počet záznamů: 1
A sex-related difference in the hypertrophic versus hyperplastic response of vascular smooth muscle cells to repeated passaging in culture
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SYSNO ASEP 0142147 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název A sex-related difference in the hypertrophic versus hyperplastic response of vascular smooth muscle cells to repeated passaging in culture Tvůrce(i) Bačáková, Lucie (FGU-C) RID, ORCID
Pellicciari, C. (IT)
Bottone, M. G. (IT)
Lisá, Věra (FGU-C)
Mareš, Vladislav (FGU-C) RIDZdroj.dok. Histology and Histopathology. - : Universidad de Murcia - ISSN 0213-3911
Roč. 16, č. 3 (2001), s. 675-684Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. ES - Španělsko Klíč. slova rat aortic smooth muscle cells ; polyploidization ; gender differences Vědní obor RIV FA - Kardiovaskulární nemoci vč. kardiochirurgie CEP IAA7011908 GA AV ČR - Akademie věd CEZ AV0Z5011922 - FGU-C Anotace We examined the impact of gender of rat donors on the degree of hyperplastic and hypertrophic responses of vascular smooth muscle cells (VSMC) in cultures subjected to repeated passaging. At pasages 40-45, the hyperplastic response, monitored by doubling time and BrdU-revealed DNA synthesis, was more intense in VSMC of male origin. Female VSMC reacted by more prominent hypertrophic changes, including increase in the volume and protein content as well as polyploidization. In addition, these cells were more effective in adhesion to the growth support (wider spreading, higher content and organization of alpha v integrin and vinculin molecules). The lower responsiveness of female-derived cells to growth stimuli may contribute to less frequent formation of hyperplastic vascular lesions in female organisms. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2002
Počet záznamů: 1