Počet záznamů: 1
Dual effects of muscarinic M2 receptors on the synthesis of cyclic AMP in CHO cells: background and model
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SYSNO ASEP 0142134 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název Dual effects of muscarinic M2 receptors on the synthesis of cyclic AMP in CHO cells: background and model Tvůrce(i) Tuček, Stanislav (FGU-C)
Michal, Pavel (FGU-C) RID
Vlachová, Viktorie (FGU-C) RID, ORCID, SAIZdroj.dok. Life Sciences. - : Elsevier - ISSN 0024-3205
Roč. 68, 22-23 (2001), s. 2501-2510Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova muscarinic receptors ; G proteins ; adenylyl cyclase Vědní obor RIV ED - Fyziologie CEP IAA7011910 GA AV ČR - Akademie věd GA309/99/0214 GA ČR - Grantová agentura ČR CEZ AV0Z5011922 - FGU-C Anotace It has been observed in several laboratories that muscarinic agonists have dual effects on the synthesis of cyclic AMP in cell lines expressing muscarinic M2 or M4 receptors, producing strong inhibition at low agonist concentrations and lesser inhibition or stimulation at high agonist concentrations. Data obtained on CHO cells (known to express adenylyl cyclases VI and VII) are best interpreted on the assumption that the upward phase of the concentration-response curves reflects simultaneous inhibition of adenylyl cyclase VI via the Gi proteins, with which the M2 and M4 receptors communicate with high affinity, and stimulation of adenylyl cyclases VI and VII via the Gs proteins, with which the M2 and M4 receptors communicate with low affinity. A simplified model is described which permits one to predict how the shapes of the concentration-response curves will be affected by changes in the concentration of receptors, the affinities of activated receptors for Gi or Gs proteins, and other parameters. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2002
Počet záznamů: 1