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Trifunctional dinuclear platinum complexes as DNA-protein cross-linking agents
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SYSNO ASEP 0104642 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Trifunctional dinuclear platinum complexes as DNA-protein cross-linking agents Title Trifunkční dvojjaderné komplexy platiny jako agens schopná vytvářet můstky mezi DNA a proteiny Author(s) Kloster, M. (US)
Kostrhunová, Hana (BFU-R) RID, ORCID
Žaludová, Renata (BFU-R)
Malina, Jaroslav (BFU-R) ORCID, RID
Kašpárková, Jana (BFU-R) RID, ORCID
Brabec, Viktor (BFU-R) RID, ORCID
Farrell, N. (US)Source Title Biochemistry. - : American Chemical Society - ISSN 0006-2960
Roč. 43, č. 24 (2004), s. 7776-7786Number of pages 11 s. Language eng - English Country US - United States Keywords DNA ; platinum ; antitumor Subject RIV BO - Biophysics R&D Projects GA301/00/0556 GA ČR - Czech Science Foundation (CSF) IAA5004101 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z5004920 - BFU-R Annotation The trifunctional dinuclear platinum compounds, 1,2/c,c, [{cis-PtCl(NH3)2}m-H2N(CH2)6NH2{cis-PtCl2(NH3)}] and 1,2/t,c, [{trans-PtCl(NH3)2}m-H2N(CH2)6NH2{cis-PtCl2(NH3)}] contain a monofunctional platinum coordination sphere linked to a cis-[PtCl2(amine)2] moiety. The compounds have been examined for their DNA binding and ability to induce covalent ternary DNA-protein crosslinks. The results indicate that the trifunctional agents may find use as protein-targetting drugs and as probes for conformational effects on DNA-protein interactions. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2005
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