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Magnetic resonance tracking of transplanted bone marrow and embryonic stem cells labeled by iron oxide nanoparticles in rat brain and spinal cord
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SYSNO ASEP 0100995 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Magnetic resonance tracking of transplanted bone marrow and embryonic stem cells labeled by iron oxide nanoparticles in rat brain and spinal cord Title Sledování transplantovaných buněk kostní dřeně a embryonálních kmenových buněk značených nanočásticemi železa magnetickou rezonancí v mozku a míše potkana Author(s) Jendelová, Pavla (UEM-P) RID, ORCID
Herynek, V. (CZ)
Urdzíková, L. (CZ)
Růžičková, Kateřina (UEM-P)
Kroupová, J. (CZ)
Andersson, Benita (UEM-P)
Bryja, Vítězslav (BFU-R) RID, ORCID
Burian, M. (CZ)
Hájek, M. (CZ)
Syková, Eva (UEM-P) RIDSource Title Journal of Neuroscience Research. - : Wiley - ISSN 0360-4012
Roč. 76, - (2004), s. 232-243Number of pages 7 s. Language eng - English Country US - United States Keywords cell transplantation ; magnetic resonance Subject RIV FH - Neurology R&D Projects GA304/03/1189 GA ČR - Czech Science Foundation (CSF) LN00A065 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) IPP1050128 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z5039906 - UEM-P MSM 11120004 Annotation Part I: In animals with a cortical photochemical lesion, the fate of GFP positive mouse Embryonic stem cells (GFP-ESCs) co-labeled with magnetic iron-oxide nanoparticles (Endorem) was studied. GFP_ESCs were either grafted intracerebrally into the contralateral hemisphere of adult rat brain or injected intravenously. In vivo MR imaging was used to track their fate; prussian blue staining and transmission electron microscopy confirmed the presence of iron-oxide nanoparticles inside the cells. The implanted cells were visible on MR images as a hypointense area at the injection site and in the lesion. The presence of GFP-positive and iron-containing cells was confirmed by subsequent histological staining. Part II: A review summarising results obtained in studies with rat nanoparticle-labeled bone marrow stromal cells (MSCs) implanted into rats with cortical photochemical lesios or spinal cord compresion lesion Workplace Institute of Experimental Medicine Contact Arzuv Čaryjeva, arzuv.caryjeva@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2005
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