Počet záznamů: 1
Vasorelaxant activity of some oxime derivatives
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SYSNO ASEP 0089191 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Vasorelaxant activity of some oxime derivatives Title Vazorelaxační aktivita některých oximových derivátů Author(s) Jaroš, F. (CZ)
Straka, T. (CZ)
Dobešová, Zdenka (FGU-C)
Pintérová, Mária (FGU-C)
Chalupský, K. (CZ)
Kuneš, Jaroslav (FGU-C) RID, ORCID
Entlicher, G. (CZ)
Zicha, Josef (FGU-C) RID, ORCID, SAISource Title European Journal of Pharmacology. - : Elsevier - ISSN 0014-2999
Roč. 575, 1-3 (2007), s. 122-126Number of pages 5 s. Language eng - English Country NL - Netherlands Keywords vasorelaxation ; Non-aromatic substituted oxime derivates Subject RIV FR - Pharmacology ; Medidal Chemistry R&D Projects 1M0510 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000250801100017 DOI https://doi.org/10.1016/j.ejphar.2007.07.040 Annotation As it is known that several non-aromatic substituted oxime derivatives function as vasorelaxant NO donors in vitro, we studied blood pressure changes elicited by administration of some of them to conscious chronically catheterized Wistar rats after acute blockade of NO synthesis. Substances with hydrophilic character were effective to induce vasorelaxation, whereas less hydrophilic or slightly hydrophobic substances were ineffective Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2008
Počet záznamů: 1