Human allogeneic keratinocytes cultured on acellular xenodermis: the use in healing of burns and other skin defects
1.
SYSNO ASEP
0044213
Druh ASEP
J - Článek v odborném periodiku
Zařazení RIV
J - Článek v odborném periodiku
Poddruh J
Ostatní články
Název
Human allogeneic keratinocytes cultured on acellular xenodermis: the use in healing of burns and other skin defects
Překlad názvu
Lidské alogenní keratinocyty kultivované na bezbuněčné xenodermis: využití pro léčbu popálenin a jiných kožních defektů
Tvůrce(i)
Matoušková, Eva (UMG-J) Brož, L. (CZ) Štolbová, V. (CZ) Klein, L. (CZ) Konigová, R. (CZ) Veselý, Pavel (UMG-J)
Zdroj.dok.
Bio-Medical Materials and Engineering
- ISSN 0959-2989
Roč. 16, č. 4 (2006), s. 63-71
Poč.str.
9 s.
Jazyk dok.
eng - angličtina
Země vyd.
NL - Nizozemsko
Klíč. slova
acellular xenodermis ; human keratinocytes ; wound grafting
Vědní obor RIV
EB - Genetika a molekulární biologie
CEP
IBS5052312 GA AV ČR - Akademie věd
CEZ
AV0Z50520514 - UMG-J (2005-2011)
Anotace
The tissue engineered skin should be composed of both dermal and epidermal layers. We combined cultured human allogeneic keratinocytes with acellular xenodermis prepared from pig xenografts. The composite skin can be cultured in undifferentiated or differentiated phenotype. The differentiated phenotype (D-RHPS) was grown at the air-liquid interface and formed 5-20 cell layers similar to the normal epidermis, including the granular and horny layers. Undifferentiated RHPS has skin-like consistency and has been successfully used for treatment of burns and skin defects using “upside-down” application. Simple acellular xenodermis without keratinocytes can also be used as temporary cover for donor sites, leg ulcers and other skin defects.
