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Anticoagulant drugs increase natural killer cell activity in lung cancer
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SYSNO ASEP 0027786 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název Anticoagulant drugs increase natural killer cell activity in lung cancer Překlad názvu Antikoagulační léčiva zvyšují aktivitu přirozených zabíječských buněk u rakoviny plic Tvůrce(i) Bobek, M. (CZ)
Boubelík, Michael (UMG-J)
Fišerová, Anna (MBU-M) RID
Luptovcová, Martina (MBU-M)
Vannucci, Luca (MBU-M) RID, ORCID
Kacprzak, G. (PL)
Kolodzej, J. (PL)
Majewski, A.M. (PL)
Hoffman, R. M. (US)Zdroj.dok. Lung Cancer. - : Elsevier - ISSN 0169-5002
Roč. 47, č. 2 (2005), s. 215-223Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. IE - Irsko Klíč. slova anticoagulant drugs ; lung cancer ; NK cells Vědní obor RIV EB - Genetika a molekulární biologie CEZ AV0Z5052915 - UMG-J Anotace We wanted to determine the effect of some anticoagulant drugs on the functional activity of natural killer (NK) cells. Cytotoxic activity in patients with early, operable stages of non-small-cell lung cancer was compared with healthy volunteers and studied in tumor-bearing animals. Patients were characterized by significantly lower NK cell cytotoxicity than healthy donors. NK cell activation was found in both in vitro experiments using PBMC from healthy donors and ex vivo in lung carcinoma patients after treatment with unfractionated heparin and fraxiparine. Similarly, potentiation of NK cell activity in Lewis lung carcinoma-bearing mice was found after therapy with unfractionated heparin. NK cell activation was increased by LMWHs. Other anticoagulants augment the effector function of NK cells in cancer patients and in an animal model of lung cancer. This is a novel effect of these compounds, which were thought previously to exert their effect only via their anticoagulant properties. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2006
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