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The Crystal Structure of Annexin A8 is Similar to that of Annexin A3
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SYSNO ASEP 0024480 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název The Crystal Structure of Annexin A8 is Similar to that of Annexin A3 Překlad názvu Krystalová struktura annexinu A8 je podobná annexinu A3 Tvůrce(i) Réty, S. (FR)
Sopková-de Oliveira Santos, J. (FR)
Dreyfuss, L. (FR)
Blondeau, K. (FR)
Hofbauerová, Kateřina (MBU-M) ORCID
Raguénes-Nicol, C. (FR)
Kerboeuf, D. (FR)
Renouard, M. (FR)
Russo-Marie, F. (FR)
Lewit-Bentley, A. (FR)Zdroj.dok. Journal of Molecular Biology. - : Elsevier - ISSN 0022-2836
Roč. 345, - (2005), s. 1131-1139Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova annexin ; x-ray crystal structure ; intact N terminus Vědní obor RIV EE - Mikrobiologie, virologie CEZ AV0Z50200510 - MBU-M (2005-2011) Anotace Annexin A8 is a relatively infrequent and poorly studied member of this large family of calcium-binding and membrane-binding proteins. It is, however, associated with a specific disease, acute promyelocytic leukemia. We have solved its three-dimensional structure, which includes a moderately long and intact N terminus. The structure is closest to that of annexin A3 and highlights several important regions of inherent flexibility in the annexin molecule. The N terminus resembles that of annexin A3, as it lies along the concave surface of the molecule and inserts partially into the hydrophilic channel in its centre. Since both annexins A3 and A8 are expressed in promyelocytic cells during their differentiation, the similarity in their structures might suggest a functional relationship Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2006
Počet záznamů: 1