Počet záznamů: 1
Metal Nanoparticles with Antimicrobial Properties: The Toxicity Response in Mouse Mesenchymal Stem Cells
- 1.
SYSNO ASEP 0581955 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Metal Nanoparticles with Antimicrobial Properties: The Toxicity Response in Mouse Mesenchymal Stem Cells Tvůrce(i) Rössner ml., Pavel (UEM-P) RID, ORCID
Červená, Tereza (UEM-P) ORCID, RID
Echalar, Barbora (UEM-P)
Palacká, Kateřina (UEM-P) ORCID
Milcová, Alena (UEM-P)
Novaková, Zuzana (UEM-P)
Šíma, Michal (UEM-P) RID, ORCID
Šímová, Zuzana (UEM-P) ORCID
Vaňková, Jolana (UEM-P)
Holáň, Vladimír (UEM-P) RIDČíslo článku 253 Zdroj.dok. Toxics. - : MDPI
Roč. 11, č. 3 (2023)Poč.str. 21 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova metal nanoparticles ; antimicrobial properties ; mesenchymal stem cells ; toxicity Obor OECD Public and environmental health CEP GA21-17720S GA ČR - Grantová agentura ČR LM2018133 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy EF16_013/0001821 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy LM2018124 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UEM-P - RVO:68378041 UT WOS 000959873500001 EID SCOPUS 85151149941 DOI 10.3390/toxics11030253 Anotace Some metal nanoparticles (NP) are characterized by antimicrobial properties with the potential to be used as alternative antibiotics. However, NP may negatively impact human organism, including mesenchymal stem cells (MSC), a cell population contributing to tissue growth and regeneration. To address these issues, we investigated the toxic effects of selected NP (Ag, ZnO, and CuO) in mouse MSC. MSC were treated with various doses of NP for 4 h, 24 h, and 48 h and multiple endpoints were analyzed. Reactive oxygen species were generated after 48 h CuO NP exposure. Lipid peroxidation was induced after 4 h and 24 h treatment, regardless of NP and/or tested dose. DNA fragmentation and oxidation induced by Ag NP showed dose responses for all the periods. For other NP, the effects were observed for shorter exposure times. The impact on the frequency of micronuclei was weak. All the tested NP increased the sensitivity of MSC to apoptosis. The cell cycle was most affected after 24 h, particularly for Ag NP treatment. In summary, the tested NP induced numerous adverse changes in MSC. These results should be taken into consideration when planning the use of NP in medical applications where MSC are involved. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2024 Elektronická adresa https://www.mdpi.com/2305-6304/11/3/253
Počet záznamů: 1