Počet záznamů: 1
Advanced micro- & nanostructuring for enhanced biocompatibility of stainless steel by multi-beam and beamshaping technology
- 1.
SYSNO ASEP 0572404 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Advanced micro- & nanostructuring for enhanced biocompatibility of stainless steel by multi-beam and beamshaping technology Tvůrce(i) Hauschwitz, Petr (FZU-D) ORCID
Klíčová, M. (CZ)
Mullerová, S. (CZ)
Bičišťová, Radka (FZU-D) ORCID
Procházka, Martin (FZU-D)
Brajer, Jan (FZU-D) ORCID
Chyla, Michal (FZU-D) RID, ORCID
Smrž, Martin (FZU-D) RID, ORCID
Chvojka, J. (CZ)
Mocek, Tomáš (FZU-D) RID, ORCID, SAICelkový počet autorů 10 Číslo článku 045008 Zdroj.dok. Biomedical Materials. - : Institute of Physics Publishing - ISSN 1748-6041
Roč. 18, č. 4 (2023)Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova biocompatibility ; lipss ; nanostructuring ; beamshaping ; cell proliferation Vědní obor RIV BH - Optika, masery a lasery Obor OECD Optics (including laser optics and quantum optics) CEP EF15_006/0000674 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora FZU-D - RVO:68378271 UT WOS 000989690300001 EID SCOPUS 85159740683 DOI 10.1088/1748-605X/acd291 Anotace Biocompatibility is one of the key issues for implants, especially in the case of stainless steel with medium to low biocompatibility, which may lead to a lack of osseointegration and consequently to implant failure or rejection. To precisely control preferential cell growth sites and, consequently, the biocompatibility of prosthetic devices, two types of surfaces were analyzed, containing periodic nanogrooves laser induced periodic surface structure (LIPSS) and square-shaped micropillars. For the fast and efficient production of these surfaces, the unique combination of high energy ultrashort pulsed laser system with multi-beam and beamshaping technology was applied, resulting in increased productivity by 526% for micropillars and 14 570% for LIPSS compared to single beam methods. In vitro analysis revealed that micro and nanostructured surfaces provide a better environment for cell attachment and proliferation compared to untreated ones, showing an increase of up to 496% in the number of cells compared to the reference. Moreover, the combination of LIPSS and micropillars resulted in a precise cell orientation along the periodic microgroove pattern. The combination of these results demonstrates the possibility of mass production of functionalized implants with control over cell organization and growth. Thus, reducing the risk of implant failure due to low biocompatibility.
Pracoviště Fyzikální ústav Kontakt Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Rok sběru 2024 Elektronická adresa https://hdl.handle.net/11104/0349449
Počet záznamů: 1