Počet záznamů: 1
Effects of systemic and renal intramedullary endothelin-1 receptor blockade on tissue NO and intrarenal hemodynamics in normotensive and hypertensive rats
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SYSNO ASEP 0565782 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Effects of systemic and renal intramedullary endothelin-1 receptor blockade on tissue NO and intrarenal hemodynamics in normotensive and hypertensive rats Tvůrce(i) Badzyńska, B. (PL)
Vaněčková, Ivana (FGU-C) RID, ORCID
Sadowski, J. (PL)
Hojná, Silvie (FGU-C) RID, ORCID
Kompanowska - Jezierska, E. (PL)Číslo článku 174445 Zdroj.dok. European Journal of Pharmacology. - : Elsevier - ISSN 0014-2999
Roč. 910, 5 Nov (2021)Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova blood pressure ; endothelin receptors ; endothelin-1 ; hypertension ; nitric oxide ; renal blood flow Obor OECD Cardiac and Cardiovascular systems Způsob publikování Open access Institucionální podpora FGU-C - RVO:67985823 UT WOS 000897620400001 EID SCOPUS 85114412055 DOI 10.1016/j.ejphar.2021.174445 Anotace Endothelin 1 (ET-1) seems essential in salt-dependent hypertension, and activation of ETA receptors causes renal vasoconstriction. However, the response in the renal medulla and the role of tissue NO availability has never been adequately explored in vivo. We examined effects of ETA and ETB receptor blockade (atrasentan and BQ788) on blood pressure (MAP), medullary blood flow (MBF) and medullary tissue NO. Effects of systemic and intramedullary blocker application were compared in anesthetized normotensive ET-1-pretreated Sprague-Dawley rats (S-D), in salt-dependent hypertension (HS/UNX) and in spontaneously hypertensive rats (SHR). Total renal blood flow (RBF) was measured using a Transonic renal artery probe, MBF as laser-Doppler flux, and tissue NO signal using selective electrodes. In normotensive rats ET-1 significantly increased MAP, decreased RBF (−20%) and renal medullary NO. In HS/UNX rats atrasentan decreased MAP and increased medullary NO, earlier and more profoundly with intravenous infusion. In SHR atrasentan decreased MAP, more effectively with intravenous infusion, the increase in tissue NO (∼10%) was similar with both routes, however, only intramedullary atrasentan increased MBF. No consistent responses to BQ788 were seen. We confirmed dominant role of ETA receptors in regulation of blood pressure and renal hemodynamics in normotensive and hypertensive rats and provided novel evidence for the role of ETA in control of intrarenal NO bioavailability in salt-dependent and spontaneous hypertension. Under conditions of activation of the endothelin system ETB stimulation preserved medullary perfusion. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2023 Elektronická adresa https://doi.org/10.1016/j.ejphar.2021.174445
Počet záznamů: 1