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Recent advances of hyaluronan for skin delivery: from structure to fabrication strategies and applications
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SYSNO ASEP 0564979 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Recent advances of hyaluronan for skin delivery: from structure to fabrication strategies and applications Tvůrce(i) Juhaščik, M. (CZ)
Kováčik, A. (CZ)
Huerta-Ángeles, Gloria (UMCH-V) ORCID, RIDČíslo článku 4833 Zdroj.dok. Polymers. - : MDPI
Roč. 14, č. 22 (2022)Poč.str. 30 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova hyaluronan ; self-assembly ; amphiphiles Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000887626400001 EID SCOPUS 85142426106 DOI 10.3390/polym14224833 Anotace Hyaluronan (HA) plays a fundamental role in maintaining the homeostasis on skin health. Furthermore, the effect of HA in skin inflammatory diseases is worth studying in the next future. HA and its conjugates change the solubility of active pharmaceutical ingredients, improve emulsion properties, prolong stability, reduce immunogenicity, and provide targeting. HA penetrates to deeper layers of the skin via several mechanisms, which depend on the macromolecular structure and composition of the formulation. The cellular and molecular mechanisms involved in epidermal dysfunction and skin aging are not well understood. Nevertheless, HA is known to selectively activate CD44-mediated keratinocyte signaling that regulates its proliferation, migration, and differentiation. The molecular size of HA is critical for molecular mechanisms and interactions with receptors. High molecular weight HA is used in emulsions and low molecular weight is used to form nanostructured lipid carriers, polymeric micelles, bioconjugates, and nanoparticles. In the fabrication of microneedles, HA is combined with other polymers to enhance mechanical properties for piercing the skin. Hence, this review aims to provide an overview of the current state of the art and last reported ways of processing, and applications in skin drug delivery, which will advocate for their broadened use in the future. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2023 Elektronická adresa https://www.mdpi.com/2073-4360/14/22/4833
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