Dual role of Fam208a during zygotic cleavage and early embryonic development

0554624 - ÚMG 2022 RIV US eng J - Článek v odborném periodiku
Grešáková, Veronika - Novosadová, Vendula - Procházková, Michaela - Procházka, Jan - Sedláček, Radislav
Dual role of Fam208a during zygotic cleavage and early embryonic development.
Experimental Cell Research. Roč. 406, č. 2 (2021), č. článku 112723. ISSN 0014-4827. E-ISSN 1090-2422
Grant CEP: GA MŠMT(CZ) LM2015040; GA MŠMT ED2.1.00/19.0395; GA MŠMT(CZ) ED1.1.00/02.0109; GA MŠMT(CZ) LQ1604; GA ČR GA15-23165S
Výzkumná infrastruktura: CCP - 90040
Institucionální podpora: RVO:68378050
Klíčová slova: Genome stability * Fam208a * Multipolar spindle apparatus * hush
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 4.145, rok: 2021
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/abs/pii/S001448272100255X?via%3Dihub

Maintenance of genome stability is essential for every living cell as genetic information is repeatedly challenged during DNA replication in each cell division event. Errors, defects, delays, and mistakes that arise during mitosis or meiosis lead to an activation of DNA repair processes and in case of their failure, programmed cell death, i.e. apoptosis, could be initiated. Fam208a is a protein whose importance in heterochromatin maintenance has been described recently. In this work, we describe the crucial role of Fam208a in sustaining genome stability during cellular division.
Trvalý link: http://hdl.handle.net/11104/0329320