Počet záznamů: 1
Affinity, Specificity, and Cooperativity of DNA Binding by Bacterial Gene Regulatory Proteins
- 1.
SYSNO ASEP 0553488 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Affinity, Specificity, and Cooperativity of DNA Binding by Bacterial Gene Regulatory Proteins Tvůrce(i) Carey, Jannette (MBU-M) ORCID Číslo článku 562 Zdroj.dok. International Journal of Molecular Sciences. - : MDPI
Roč. 23, č. 1 (2022)Poč.str. 16 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova escherichia-coli ; ligand-binding ; trp-repressor ; thermodynamics ; conformations ; constraints ; mutants ; domain ; biological constraints ; host-guest chemistry ; pre-organization ; cryptic thermodynamic factors ; protein folding coupled to ligand binding ; gestalt properties of proteins ; drug design Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Microbiology Způsob publikování Open access Institucionální podpora MBU-M - RVO:61388971 UT WOS 000741453200001 EID SCOPUS 85122384956 DOI 10.3390/ijms23010562 Anotace Nearly all of biology depends on interactions between molecules: proteins with small molecules, proteins with other proteins, nucleic acids with small molecules, and nucleic acids with proteins that regulate gene expression, our concern in this Special Issue. All those kinds of interactions, and others, constitute the vast majority of biology at the molecular level. An understanding of those interactions requires that we quantify them to learn how they interact: How strongly? With which partners? How-and how well-are different partners distinguished? This review addresses the evolution of our current understanding of the molecular origins of affinity and specificity in regulatory protein-DNA interactions, and suggests that both these properties can be modulated by cooperativity. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2023 Elektronická adresa https://www.mdpi.com/1422-0067/23/1/562
Počet záznamů: 1