Počet záznamů: 1
Oxidative stress and Rho GTPases in the biogenesis of tunnelling nanotubes: implications in disease and therapy
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SYSNO ASEP 0550581 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Oxidative stress and Rho GTPases in the biogenesis of tunnelling nanotubes: implications in disease and therapy Tvůrce(i) Raghavan, A. (IN)
Rao, P. (IN)
Neužil, Jiří (BTO-N) RID
Pountney, D. L. (AU)
Nath, S. (IN)Celkový počet autorů 5 Zdroj.dok. Cellular and Molecular Life Sciences - ISSN 1420-682X
Roč. 79, č. 1 (2022)Poč.str. 15 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova mesenchymal stem-cells ; fibrillar alpha-synuclein ; multipotent stromal cells ; mitochondrial transfer ; in-vitro ; membrane nanotubes Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Biochemistry and molecular biology Způsob publikování Open access Institucionální podpora BTO-N - RVO:86652036 UT WOS 000731194700001 EID SCOPUS 85121339487 DOI 10.1007/s00018-021-04040-0 Anotace Tunnelling nanotubes (TNTs) are an emerging route of long-range intercellular communication that mediate cell-to-cell exchange of cargo and organelles and contribute to maintaining cellular homeostasis by balancing diverse cellular stresses. Besides their role in intercellular communication, TNTs are implicated in several ways in health and disease. Transfer of pathogenic molecules or structures via TNTs can promote the progression of neurodegenerative diseases, cancer malignancy, and the spread of viral infection. Additionally, TNTs contribute to acquiring resistance to cancer therapy, probably via their ability to rescue cells by ameliorating various pathological stresses, such as oxidative stress, reactive oxygen species (ROS), mitochondrial dysfunction, and apoptotic stress. Moreover, mesenchymal stem cells play a crucial role in the rejuvenation of targeted cells with mitochondrial heteroplasmy and oxidative stress by transferring healthy mitochondria through TNTs. Recent research has focussed on uncovering the key regulatory molecules involved in the biogenesis of TNTs. However further work will be required to provide detailed understanding of TNT regulation. In this review, we discuss possible associations with Rho GTPases linked to oxidative stress and apoptotic signals in biogenesis pathways of TNTs and summarize how intercellular trafficking of cargo and organelles, including mitochondria, via TNTs plays a crucial role in disease progression and also in rejuvenation/therapy. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2023 Elektronická adresa https://link.springer.com/article/10.1007/s00018-021-04040-0
Počet záznamů: 1