Počet záznamů: 1
Total synthesis of inubosin B
- 1.0535965 - ÚOCHB 2021 RIV GB eng J - Článek v odborném periodiku
Hamissa, Mohamed Farouk - Niederhafner, Petr - Šafařík, Martin - Telus, M. - Kolářová, Lenka - Koutná, Leah - Šestáková, H. - Souček, Radko - Šebestík, Jaroslav
Total synthesis of inubosin B.
Tetrahedron Letters. Roč. 61, č. 52 (2020), č. článku 152641. ISSN 0040-4039. E-ISSN 1873-3581
Grant CEP: GA ČR(CZ) GA17-00121S; GA MŠMT(CZ) EF16_019/0000729
Institucionální podpora: RVO:61388963
Klíčová slova: neuroregeneration * neurodegeneration * acridine * alkaloid * total synthesis
Obor OECD: Biophysics
Impakt faktor: 2.415, rok: 2020
Způsob publikování: Omezený přístup
https://doi.org/10.1016/j.tetlet.2020.152641
Inubosin B is the most active member of the acridine alkaloids isolated from Streptomyces sp. IFM 11440 culture. The inubosins initiate neuroregeneration via a neurogenine 2 pathway. In this work, we have described the total synthesis of inubosin B via two synthetic routes. The effects of various coupling, cyclization and reduction reactions are discussed including common pitfalls and side reactions. Reverse phase chromatography with TFA was crucial for the isolation of the product from aluminum ions present in the reduction media.
Trvalý link: http://hdl.handle.net/11104/0313970
Počet záznamů: 1