Radiolabeled hormones in insulin research, a minireview

0533542 - ÚOCHB 2021 RIV GB eng J - Článek v odborném periodiku
Jiráček, Jiří - Žáková, Lenka - Marek, Aleš
Radiolabeled hormones in insulin research, a minireview.
Journal of Labelled Compounds and Radiopharmaceuticals. Roč. 63, č. 14 (2020), s. 576-581. ISSN 0362-4803. E-ISSN 1099-1344
Grant CEP: GA MŠMT(CZ) EF16_019/0000729; GA ČR(CZ) GA19-14069S
Institucionální podpora: RVO:61388963
Klíčová slova: assay * binding * hormone * IGF * insulin * radiolabeling * receptor
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 1.921, rok: 2020
Způsob publikování: Omezený přístup
https://doi.org/10.1002/jlcr.3881

This minireview briefly summarizes a history of insulin research employing iodinated insulin-like hormones. Preparation of both 125I-labeled insulin and insulin-like growth factor 1 (IGF-1) was critical because it enabled a detailed characterization of binding properties of these important hormones towards their cognate transmembrane receptors. Binding modes of hundreds of hormone derivatives were analyzed using competition radioligand binding assays. This effort has resulted in development of six insulin analogs that are today clinically used for the treatment of diabetes.
Trvalý link: http://hdl.handle.net/11104/0312368