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Structure degradation and strength changes of sintered calcium phosphate bone scaffolds with different phase structures during simulated biodegradation in vitro
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SYSNO ASEP 0511559 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Structure degradation and strength changes of sintered calcium phosphate bone scaffolds with different phase structures during simulated biodegradation in vitro Tvůrce(i) Šťastný, P. (CZ)
Sedláček, R. (CZ)
Suchý, Tomáš (USMH-B) RID, ORCID, SAI
Lukášová, Věra (UEM-P)
Rampichová, Michala (UEM-P) RID, ORCID
Trunec, M. (CZ)Zdroj.dok. Materials Science & Engineering C-Materials for Biological Applications. - : Elsevier - ISSN 0928-4931
Roč. 100, JUL 2019 (2019), s. 544-553Poč.str. 10 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Scaffold ; Calcium phosphate ; Phase composition ; Degradation ; Compressive strength ; Cell response Vědní obor RIV JH - Keramika, žáruvzdorné materiály a skla Obor OECD Medical engineering Vědní obor RIV – spolupráce Ústav experimentální medicíny - Biotechnologie a bionika CEP GA18-09306S GA ČR - Grantová agentura ČR GA16-14758S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora USMH-B - RVO:67985891 ; UEM-P - RVO:68378041 UT WOS 000466059700053 EID SCOPUS 85062829153 DOI 10.1016/j.msec.2019.03.027 Anotace The structure degradation and strength changes of calcium phosphate scaffolds after long-term exposure to an acidic environment simulating the osteoclastic activity were determined and compared. Sintered calcium phosphate scaffolds with different phase structures were prepared with a similar cellular pore structure and an open porosity of over 80%. Due to microstructural features the biphasic calcium phosphate (BCP) scaffolds had a higher compressive strength of 1.7 MPa compared with the hydroxyapatite (HA) and beta-tricalcium phosphate (TCP) scaffolds, which exhibited a similar strength of 1.2 MPa. After exposure to an acidic buffer solution of pH = 5.5, the strength of the HA scaffolds did not change over 14 days. On the other hand, the strength of the TCP scaffolds decreased steeply in the first 2 days and reached a negligible value of 0.09 MPa after 14 days. The strength of the BCP scaffolds showed a steady decrease with a reasonable value of 0.5 MPa after 14 days. The mass loss, phase composition and microstructural changes of the scaffolds during degradation in the acidic environment were investigated and a mechanism of scaffold degradation was proposed. The BCP scaffold showed the best cell response in the in vitro tests. The BCP scaffold structure with the highly soluble phase (alpha-TCP) embedded in a less soluble matrix (beta-TCP/HA) exhibited a controllable degradation with a suitable strength stability and with beneficial biological behavior it represented the preferred calcium phosphate structure for a resorbable bone scaffold. Pracoviště Ústav struktury a mechaniky hornin Kontakt Iva Švihálková, svihalkova@irsm.cas.cz, Tel.: 266 009 216 Rok sběru 2020 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0928493118339717?via%3Dihub
Počet záznamů: 1